Assessment of anti-seizure properties of two proprietary compounds in the electrical kindling model of epilepsy Date
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The effect of parameters of low-frequency electrical stimulation on piriform-cortex kindled seizures in rat
Introduction: Electrical low-frequency stimulation (LFS) has antiepileptic effect, but the role of different stimulation parameters on this effect has not been determined. In this study the effect of different LFS parameters (intensity, pulse duration and train duration) on piriform-cortex kindled seizures was investigated. Methods: Seizure was produced in animals using kindling model of ep...
متن کاملبررسی کیندلینگ الکتریکی به وسیله تحریکات الکتریکی مکرر کف پای موش صحرایی
Background and purpose: Kindling is an animal model of epilepsy induced by repeated stimulation of the brain. The amygdala has been the focus of interest due to large part to its role in epilepsy induction and in fear conditioning in both human and rats. The purpose of the present study was to evaluate whether low electrical stimulation of foot pad of rats during fear can facilitate amygdala...
متن کاملStudy of Anticonvulsant Effects of Carbamazepine During Epileptic Process by Unilateral Kindling of CA1 Dorsal Hippocampus in Adult Male Rats
Introduction: Epilepsy is a chronic and multifactorial disease with recurrent seizures. Carbamazepine is the most common drug used to treat epilepsy. In this research project, the anticonvulsant effects of carbamazepine on the seizure parameters in adult male rats during dorsal hippocampal are investigated epilepsy by electrical kindling method. Methods: This study is experimental. In this stu...
متن کاملInhibitory Effect of High Dose of the Flavonoid Quercetin on Amygdala Electrical Kindling in Rats
A B S T R A C T Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures. Although the most commonly recommended therapy is drug treatment, some patients do not achieve adequate control of their seizures on existing drugs. New medications with novel mechanisms of action are needed to help those patients whose seizures are resistant to...
متن کاملMethanol leaf extract of Albizia chevalieri harms possesses anticonvulsant activity in acute and chronic models of epilepsy
Background & Aim:Albizia chevalieri Harms (Mimosaceae) is widely used in traditional medicine to treat various kinds of diseases such as epilepsy, diabetes mellitus, hemorrhoids, asthma, leprosy and gonorrhoea. The effectiveness of its leaf extract in the management of epilepsy is widely acclaimed among communities in northern Nigeria. This study aimed at evaluating th...
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تاریخ انتشار 2007